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Nuclear for Healthcare
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Targeted Alpha Therapy with Lead-212 against Cancer
Discover a breakthrough therapeutic innovation : the development of targeted alpha therapies in oncology leveraging the unique properties of lead-212.
1
Challenges
Address unmet medical needs
for numerous cancers
Open promising prospects for
patients
not
responding to existing treatments
2
Our Solution
Develop a new generation of targeted therapies against cancer using the unique properties of lead-212 (
212
Pb),
a rare alpha-emitting radioisotope and one of the most potent therapeutic payloads against cancer cells
Focus research on pathologies where unmet medical needs remain significant
Accelerate the transition from research to clinic
through dedicated infrastructures
Rely on production capacities in France and the United States
to secure the supply of these therapies for clinical trials and potential commercialization
Shorter range of alpha particles : 2 to 5 cell layers
Less than 5 alpha emissions to destroy a tumor cell
3
Key Features
2009
: creation of Orano Med following promising studies conducted by Areva (ex Orano) with the U.S. National Cancer Institute
+10 years of research and development
in targeted alpha therapy
High biological efficacy
: alpha particles from ²¹²Pb cause irreparable double-strand DNA breaks, leading to rapid destruction of cancer cells
(fewer than 5 alpha emissions are required to destroy a tumor cell)
Reduced toxicity
: short range of alpha particles (
2 to 5 cell layers
), minimizing impact on surrounding healthy tissues
Half-life of 10.6 hours
: suitable for outpatient administration and simplified radioactive waste management
Clean decay chain:
a single alpha emission, reducing the risk of off-target toxicity
Effective targeting
of cancer cells
through R&D and the use of stable, high-performance chelators
Theranostic compatibility
with lead-203, a gamma emitter suitable for treatment monitoring through imaging
4
Useful Links
Video: How 212Pb Alpha Therapy Is Changing Cancer Care
Discover Orano Med – Official Website
Video – Lead-212: Mechanism of Action Explained
